Speaker: Christian Dölle, Neuro-SysMed researcher on Parkinson’s Disease and NAD-metabolism at the University of Bergen and Haukeland University Hospital
Chair: Charalampos Tzoulis
Title: Cell models for Parkinson`s Disease
Place: The auditorium in Bikuben, Jonas Lies vei 69 (campus Haukeland University Hospital)
Time: Wednesday February 15 at 11:30 – 13:00 (lunch from 11:30 – 12:00).
Registration link: please use this link
Deadline is Feb. 10 at 11.00 if you want to join the lunch. If not, you can register till it starts.
Abstract: Parkinson`s disease is a complex neurodegenerative disorder. Despite great efforts, the mechanisms leading to and propagating the disease are still far from understood. Clinical trials and studies are vital to gain insight in the disease and test new promising treatment regimens, however, they also come with challenges such as immense costs, long durations, and restricted sampling possibilities. Therefore, research using animal and cell models is essential to provide new insights and generate hypotheses that eventually can be tested in patients.While cell models are limited and not able to exactly replicate the complexity of the disease, they can be successfully applied to investigate distinct aspects of the disease, such as mitochondrial dysfunction or aberrant protein homeostasis. Several models exist, including genetic and pharmacological models, and employ different cell lines to represent different cell- and tissue types, depending on the research question. These cell models have several advantageous characteristics, such as basic maintenance requirements, reproducibility, versatility, and virtually limitless sample access.An overview of different model systems and approaches will be given, along with examples of the models used in our lab.
Who: Open for all interested
Lecture language: English
ECTS: Participation provides ECTS for PhD candidates and is part of the Neuro-SysMed Graduate School of Translational Neuroscience. If you are a UiB student, make sure you register each term in Studentweb for the subject NEUROSYSM920 Neuro-Sysmed seminars and symposium.
Seminar coordinators: Cecilie Kristiansen and Sam Anandan.