Recent publications by researchers in the centre

Neuro-SysMed[Affiliation]

• Prevalence, risk factors, clinical and biochemical characteristics of Alemtuzumab-induced Graves' disease September 14, 2023
  CONCLUSION: GD is a very common complication of alemtuzumab treatment and is characterized by alternating hyper- and hypothyroidism. Both remission rates and the prevalence of TED were lower than those reported for conventional GD. Pregnancies were uncomplicated and GD was associated with a lower risk of subsequent MS activity.
  Grethe Åstrøm Ueland
• Impaired glucose utilization in the brain of patients with delirium following hip fracture September 2, 2023
  Alterations in brain energy metabolism have long been proposed as one of several neurobiological processes contributing to delirium. This is supported by previous findings of altered CSF lactate and neuron-specific enolase concentrations and decreased glucose uptake on brain-PET in patients with delirium. Despite this, there is limited data on metabolic alterations found in CSF samples, […]
  Irit Titlestad
• Application of Flow Cytometric Analysis for Measuring Multiple Mitochondrial Parameters in 3D Brain Organoids August 17, 2023
  Mitochondrial dysfunction is a common primary or secondary contributor to many types of neurodegeneration, and changes in mitochondrial mass, mitochondrial respiratory chain (MRC) complexes, and mitochondrial DNA (mtDNA) copy number often feature in these processes. Human brain organoids derived from human induced pluripotent stem cells (iPSCs) recapitulate the brain's three-dimensional (3D) cytoarchitectural arrangement and offer […]
  Sharika Marjan
• Deoxyribonucleoside treatment rescues EtBr-induced mtDNA depletion in iPSC-derived neural stem cells with POLG mutations August 16, 2023
  Mutations in POLG, the gene encoding the catalytic subunit of the mitochondrial DNA (mtDNA) polymerase gamma (Pol-γ), lead to diseases driven by defective mtDNA maintenance. Despite being the most prevalent cause of mitochondrial disease, treatments for POLG-related disorders remain elusive. In this study, we used POLG patient-induced pluripotent stem cell (iPSC)-derived neural stem cells (iNSCs), […]
  Cecilie Katrin Kristiansen
• DNA Methylation Age Acceleration Is Not Associated with Age of Onset in Parkinson's Disease August 8, 2023
  CONCLUSIONS: Our findings refute the previously reported inverse relationship between DNAm age acceleration and age of onset in PD. We show that these findings are fully accounted for by an expected over/underestimation of DNAm age in younger/older individuals. Furthermore, this effect is likely to be responsible for nearly identical findings reported in other neurodegenerative diseases. […]
  Johannes J Gaare
• Childbirth delivery mode and the risk of multiple sclerosis: a prospective population-based study July 21, 2023
  CONCLUSIONS: CS was associated with a modestly higher risk of developing MS. However, the stronger associations seen in subgroups who likely experienced a more complicated pregnancy/delivery may point to confounding underlying these associations.
  Akash Kapali
• Neuronal loss drives differentially expressed protein-pathways in the PSP globus pallidus July 10, 2023
  No abstract
  Fiona Dick
• Microstructural changes precede depression in patients with relapsing-remitting Multiple Sclerosis June 22, 2023
  CONCLUSIONS: Our data suggests a relationship between higher levels of free-water in the subcortical structures in an early stage of Multiple Sclerosis and depression symptoms at a later stage of the disease.
  Frank Riemer
• Not every estimate counts - evaluation of cell composition estimation approaches in brain bulk tissue data June 7, 2023
  CONCLUSIONS: Our work indicates that cell composition estimation or direct quantification in one tissue sample should not be used as a proxy to the cellular composition of another tissue sample from the same brain region of an individual-even if the samples are directly adjacent. The highly similar outcomes observed among vastly different estimation methods, highlight […]
  Lilah Toker
• Higher concentrations of kynurenic acid in CSF are associated with the slower clinical progression of Alzheimer's disease June 2, 2023
  INTRODUCTION: The kynurenine pathway's (KP) malfunction is closely related to Alzheimer's disease (AD), for antagonistic kynurenic acid (KA) and agonistic quinolinic acid act on the N-methyl-D-aspartate receptor, a possible therapeutic target in treating AD.
  Anne-Brita Knapskog
• Treatment of motor symptoms in Parkinson's disease May 9, 2023
  In recent years, the development of new therapies and improvements in our understanding of older therapies have led to changes in the management of Parkinson's disease. However, current Norwegian and international therapy recommendations present a range of different options as being equally viable. In this clinical review, we propose an updated algorithm for the medical […]
  Espen Dietrichs
• POLG genotype influences degree of mitochondrial dysfunction in iPSC derived neural progenitors, but not the parent iPSC or derived glia April 27, 2023
  Diseases caused by POLG mutations are the most common form of mitochondrial diseases and associated with phenotypes of varying severity. Clinical studies have shown that patients with compound heterozygous POLG mutations have a lower survival rate than patients with homozygous mutations, but the molecular mechanisms behind this remain unexplored. Using an induced pluripotent stem cell […]
  Yu Hong