Recent publications by researchers in the centre

Neuro-SysMed[Affiliation]

• Brain atrophy and clinical characteristics predicting SDMT performance in multiple sclerosis: A 10-year follow-up study February 24, 2021
  CONCLUSION: This longitudinal study shows that baseline MRI-markers, demographic and clinical data can help predict worsening IPS. Identification of patients at risk of IPS decline is of importance as follow-up, treatment and rehabilitation can be optimized.
  Cecilie Jacobsen
• Cerebrospinal fluid proteome shows disrupted neuronal development in multiple sclerosis February 19, 2021
  Despite intensive research, the aetiology of multiple sclerosis (MS) remains unknown. Cerebrospinal fluid proteomics has the potential to reveal mechanisms of MS pathogenesis, but analyses must account for disease heterogeneity. We previously reported explorative multivariate analysis by hierarchical clustering of proteomics data of MS patients and controls, which resulted in two groups of individuals. Grouping […]
  Ellen F Mosleth
• Paraneoplastic Cerebellar Degeneration: The Importance of Including CDR2L as a Diagnostic Marker February 3, 2021
  CONCLUSIONS: Commercially available tests for Yo antibody detection have low specificity for PCD because these assays use CDR2 as antigen. By adding a test for CDR2L, which is the major Yo antigen, the accuracy of PCD diagnosis greatly improved.
  Ida Herdlevær
• Serum markers of multiple sclerosis - a new approach January 30, 2021
  No abstract
  Øivind Torkildsen
• Serum biomarkers in primary mitochondrial disorders January 27, 2021
  The aim of this study was to explore the utility of the serum biomarkers neurofilament light chain, fibroblast growth factor 21 and growth and differentiation factor 15 in diagnosing primary mitochondrial disorders. We measured serum neurofilament light chain, fibroblast growth factor 21 and growth and differentiation factor 15 in 26 patients with a genetically proven […]
  Kristin N Varhaug
• Comorbidity in multiple sclerosis patients from Nordland County, Norway - validated data from the Norwegian Patient Registry December 28, 2020
  CONCLUSION: Compared to reports from other Norwegian epidemiological studies, a higher proportion of inflammatory bowel disease and epilepsy was found. This is in accordance with findings from other studies. The prevalence of non-melanoma skin cancers was significantly higher than in the general Norwegian population as they were reported by The Cancer Registry of Norway.
  Espen Benjaminsen
• A two-year longitudinal follow-up of cognitive performance assessed by BICAMS in newly diagnosed patients with MS December 10, 2020
  CONCLUSION: The patients showed improved test results from baseline to the first follow-up examination, indicating that an effect of previous practise should be taken into account when interpreting the results. With results showing both trajectories of stability and change, our study supported the validity of including BICAMS as part of a clinical follow-up routine of […]
  Ellen Skorve
• N-acetylcysteine amide ameliorates mitochondrial dysfunction and reduces oxidative stress in hiPSC-derived dopaminergic neurons with POLG mutation December 2, 2020
  The inability to reliably replicate mitochondrial DNA (mtDNA) by mitochondrial DNA polymerase gamma (POLG) leads to a subset of common mitochondrial diseases associated with neuronal death and depletion of neuronal mtDNA. Defining disease mechanisms in neurons remains difficult due to the limited access to human tissue. Using human induced pluripotent stem cells (hiPSCs), we generated […]
  Kristina Xiao Liang
• BMP5/7 protect dopaminergic neurons in an α -synuclein mouse model of Parkinson's disease November 30, 2020
  No abstract
  Zagorka Vitic
• Differential transcript usage in the Parkinson's disease brain November 2, 2020
  Studies of differential gene expression have identified several molecular signatures and pathways associated with Parkinson's disease (PD). The role of isoform switches and differential transcript usage (DTU) remains, however, unexplored. Here, we report the first genome-wide study of DTU in PD. We performed RNA sequencing following ribosomal RNA depletion in prefrontal cortex samples of 49 […]
  Fiona Dick
• A method for differentiating human induced pluripotent stem cells toward functional cardiomyocytes in 96-well microplates October 29, 2020
  The capacity of pluripotent stem cells both for self-renewal and to differentiate into any cell type have made them a powerful tool for studying human disease. Protocols for efficient differentiation towards cardiomyocytes using defined, serum-free culture medium combined with small molecules have been developed, but thus far, limited to larger formats. We adapted protocols for […]
  Novin Balafkan
• Tenofovir as a treatment option for multiple sclerosis October 13, 2020
  Some antiretroviral medications are also inhibitors of EBV. We describe a patient with highly active MS who was infected with HIV and started HIV-treatment containing tenofovir alafenamide (TAF), a potent inhibitor of EBV lytic reactivation. Her MS was in complete remission during this treatment, and she had new radiological disease activity again after switching to […]
  Øivind Torkildsen