Professor Jog is an internationally renowned expert in movement disorders, including dystonia, tremor, ataxia and Parkinson’s disease, and runs a state-of-theart centre dedicated to the diagnosis and treatment of patients with these common and debilitating disorders. He is also widely acknowledged as a leader in research and innovation in the fields of movement disorders and neurodegeneration. Professor Jog’s early research advanced the understanding of how neuronal networks function in animal models. He then transferred these findings to the clinic and translated them into novel therapeutic approaches as well as smart technologies to objectify clinical assessment and treatment of patients. His seminal scientific work has made outstanding contributions to improving the care and quality of life of patients with movement disorders.

Prominent examples of Professor Jog’s work include using spinal cord stimulation for gait dysfunction treatment in Parkinson’s disease, with impressive results.
In another major scientific and clinical contribution, Professor Jog and his team established innovative machine learning algorithms improving the outcome of injection therapy for patients with cervical dystonia and tremor. Professor Jog’s lab has recently discovered that brain injections with botulinum toxin (a drug that is already in clinical use for other indications) hold potential as a novel treatment alternative for patients with Parkinson’s disease and potentially other movement disorders. Professor Jog’s work has led to substantial innovation and commercial value generation, including the establishment of several start-up businesses.

Professor Jog has a key role in the design and implementation of clinical cohort studies as well as randomized clinical trials for PD, such as the ongoing NO-PARK, NAD-PARK and STRAT-PARK studies. These trials employ innovative approaches for objective patient assessment, which are enabled by technologies developed by Professor Jog’s lab, such as wireless whole-body wearable sensors with accompanying computational algorithms.

Selected Key Publications

1. Shahtalebi S. et al. PHTNet: Characterization and Deep Mining of Involuntary Pathological Hand Tremor using Recurrent Neural Network Models. Sci Rep. 2020 Feb 10;10(1):2195. PMID: 32042111
2. Hui D. et al. Assessing the effect of current steering on the total electrical energy delivered and ambulation in Parkinson’s disease. Sci Rep. 2020;10(1):8256. 2020 May 19. doi:10.1038/s41598-020-64250-7
3. Jog M. et al. Tolerability and Efficacy of Customized IncobotulinumtoxinA Injections for Essential Tremor: A Randomized, Double-Blind, Placebo-Controlled Study. Toxins (Basel). 2020 Dec 20;12(12):807. doi: 10.3390/toxins12120807. PMID: 33419261; PMCID: PMC7766785.
4. Samotus O. et al. Standardized algorithm for muscle selection and dosing of botulinum toxin for Parkinson tremor using kinematic analysis. Ther Adv Neurol Disord. 2020 Sep 23;13:1756286420954083. doi:10.1177/1756286420954083. PMID: 33014139; PMCID: PMC7517980.
5. Samotus O. et al. Spinal cord stimulation therapy for gait dysfunction in progressive supranuclear palsy patients. J Neurol. 2020 Oct 3. doi: 10.1007/s00415-020-10233-7. Epub ahead of print. PMID: 33011852
6. Knowles T. et al. A Comparison of Speech Amplification and Personal Communication Devices for Hypophonia. J Speech Lang Hear Res. 2020 Aug 10;63(8):2695-2712. doi: 10.1044/2020_JSLHR-20-00085. Epub 2020 Aug 5. PMID: 32755496.
7. Samotus O. et al. Spinal Cord Stimulation Therapy for Gait Dysfunction in Two Corticobasal Syndrome Patients. Can J Neurol Sci. 2020 Jul 10:1-3. doi: 10.1017/cjn.2020.143. Epub ahead of print. PMID: 32646537.
8. Samotus O. et al. Long-term update of the effect of spinal cord stimulation in advanced Parkinson’s disease patients. Brain Stimul. 2020 Sep-Oct;13(5):1196-1197. doi: 10.1016/j.brs.2020.06.004. Epub 2020 Jun 3. PMID: 32504828.
9. Adams S. et al. Efficacy and Acceptance of a Lombardresponse Device for Hypophonia in Parkinson’s Disease. Can J Neurol Sci. 2020 Sep;47(5):634-641. doi: 10.1017/cjn.2020.90. Epub 2020 May 11. PMID: 32389143.
10. Khosravi M. et al. Intraoperative Localization of STN During DBS Surgery Using a Data-Driven Model. IEEE J Transl Eng Health Med. 2020;8:2500309. Published 2020 Jan 30. doi:10.1109/JTEHM.2020.2969152
11. Mittal SO. et al. Novel Botulinum Toxin Injection Protocols for Parkinson Tremor and Essential Tremor – the Yale Technique and Sensor-Based Kinematics Procedure for Safe and Effective Treatment. Tremor Other Hyperkinet Mov (N Y). 2020 Dec 31;10:61. doi: 10.5334/tohm.582. PMID: 33442486; PMCID: PMC7774361.
12. Page AD. et al. Exploring the Psychosocial Impact of Botulinum Toxin Type A Injections for Individuals With Oromandibular Dystonia: A Qualitative Study of Patients’ Experiences. Am J Speech Lang Pathol. 2021 Feb 25:1-15. doi: 10.1044/2020_AJSLP-20-00124. Epub ahead of print. PMID: 33647215.

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